A metastasectomy is procedure performed in the operating room in which melanoma metastases are removed surgically from distant organs. Melanoma has the ability to travel to any organ in the body. Patients with a high risk melanoma require frequent skin screening and imaging with the goal of detecting distant metastases at an early stage. Patients that have evidence of distant disease that is slow growing and are healthy enough to undergo surgery, may benefit from a metastasectomy. Not all patients with distant melanoma metastases will be candidates for this procedure.